genetics
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The latest volume of HD genetics research reveals new gems but also mysteries
Each person with HD has genetic spelling changes that can impact HD symptoms. Scientists have released the latest in a series of genetic studies examining these spelling changes, shining a light on new paths to develop treatments for HD.
By Dr Chris Kay -
Red Light, Green Light: How Huntington’s Disease Influences Genetic Traffic Lights
Huntington’s disease disrupts genetic "traffic lights," keeping genes green when they should be red. These genetic traffic jams may act to speed brain cell aging and faulty traffic cops fail to stop the chaos. What does this mean for HD?
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Navigating the Genetic River: How Tiny Variants Could Shift the Course of Huntington’s Disease
Hidden twists in the Huntington’s disease gene could shift symptoms by over a decade! Scientists have uncovered rare “genetic dams” that shape when HD begins – sometimes dramatically
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Knockouts for the win: how expanding CAGs drive disease
A recent paper links CAG repeat expansion with widespread RNA changes, especially in brain cells vulnerable to HD. “Knocking out” certain DNA repair genes that go awry in HD can have positive effects on features of HD in mice.
By Dr Leora Fox -
We are not alone, and are seeing more RED
Scientists have found more people have the genetic changes that underlie repeat expansion diseases, like HD, than previously thought. This new data tells doctors to consider expansion diseases more when diagnosing people with neurological symptoms.
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Understanding expansions at the single cell level
Scientists have looked at CAG expansions in brains from people with HD to see which cells are affected
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Tipping the balance; new insights into HD genetic modifiers
A new study from researchers at Thomas Jefferson University delves into the details of how genetic modifiers of Huntington’s disease work.
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Unpacking recent gene therapy press
Voyager Therapeutics is shifting towards a new technology to deliver gene therapy and away from a planned HD clinical trial. But this could lead to less invasive drugs in the long run, and many other companies are working on HD gene therapies.
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Huntington’s disease therapeutics conference 2020 – Day 3
HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs
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Huntington’s disease therapeutics conference 2020 – Day 2
HDBuzz reports from the annual Huntington’s disease therapeutics conference in Palm Springs